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Case of the week  38 ( February 2012 )

Ocular Myasthenia Gravis

 



8 months ago, this healthy 18 year- old boy  was noted by his parents to have his eyes turned in only at night , every day at night he develops esotropia till he sleeps , the following morning he wakes up with straight nice eyes , remains orthotropic all the day , then when the sun sets his eyes turn in again  
 





Ocular Myasthenia Gravis

Myasthenia gravis is an autoimmune disease that affects the receptors for acetylcholine at the neuromuscular junction .

Ocular myasthenia gravis is a type of myasthenia gravis that only affects the eyes and eyelid movement. The hallmark of ocular myasthenia gravis is eye muscle weakness that increases during activity and improves after rest.


Some individuals with myasthenia gravis develop thymomas (tumors of the thymus gland). Thymomas are generally benign, but they can become malignant.

 Symptoms :

·         Drooping of one or both eyelids

·         Double vision and variable ocular deviations .

Tests For MG :

Clinical Tests
There are two special clinical tests that the doctor might perform looking for MG. These are the ice test and the Tensilon test.

Blood Test : acetylcholine receptor antibodies.

Nerve Conduction Study & (EMG)

 (CT) Scan for the thymus

Treatment Options

Medications  : anticholinesterase agents such as neostigmine and pyridostigmine

Thymectomy

Assistive Devices : Eyelid crutches ,   Eyelid tape , Eyeglass prisms

Prognosis for Ocular Myasthenia Gravis

In most cases, ocular myasthenia gravis is usually the earliest form of myasthenia gravis to appear. More than 50 percent of people with ocular myasthenia gravis will develop generalized myasthenia gravis .

 

 


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